Neutrophils and PMN-MDSC: Their biological role and interaction with stromal cells

J Zhou, Y Nefedova, A Lei, D Gabrilovich - Seminars in immunology, 2018 - Elsevier
J Zhou, Y Nefedova, A Lei, D Gabrilovich
Seminars in immunology, 2018Elsevier
Neutrophils and polymorphonucler myeloid-derived suppressor cells (PMN-MDSC) share
origin and many morphological and phenotypic features. However, they have different
biological role. Neutrophils are one of the major mechanisms of protection against invading
pathogens, whereas PMN-MDSC have immune suppressive activity and restrict immune
responses in cancer, chronic infectious disease, trauma, sepsis, and many other
pathological conditions. Although in healthy adult individuals, PMN-MDSC are not or barely …
Abstract
Neutrophils and polymorphonucler myeloid-derived suppressor cells (PMN-MDSC) share origin and many morphological and phenotypic features. However, they have different biological role. Neutrophils are one of the major mechanisms of protection against invading pathogens, whereas PMN-MDSC have immune suppressive activity and restrict immune responses in cancer, chronic infectious disease, trauma, sepsis, and many other pathological conditions. Although in healthy adult individuals, PMN-MDSC are not or barely detectable, in patients with cancer and many other diseases they accumulate at various degree and co-exist with neutrophils. Recent advances allow for better distinction of these cells and better understanding of their biological role. Accumulating evidence indicates PMN-MDSC as pathologically activated neutrophils, with important role in regulation of immune responses. In this review, we provide an overview on the definition and characterization of PMN-MDSC and neutrophils, their pathological significance in a variety of diseases, and their interaction with other stromal components.
Elsevier