Impact of oncogenic pathways on evasion of antitumour immune responses

S Spranger, TF Gajewski - Nature Reviews Cancer, 2018 - nature.com
Nature Reviews Cancer, 2018nature.com
Immunotherapeutic interventions are showing effectiveness across a wide range of cancer
types, but only a subset of patients shows clinical response to therapy. Responsiveness to
checkpoint blockade immunotherapy is favoured by the presence of a local, CD8+ T cell-
based immune response within the tumour microenvironment. As molecular analyses of
tumours containing or lacking a productive CD8+ T cell infiltrate are being pursued,
increasing evidence is indicating that activation of oncogenic pathways in tumour cells can …
Abstract
Immunotherapeutic interventions are showing effectiveness across a wide range of cancer types, but only a subset of patients shows clinical response to therapy. Responsiveness to checkpoint blockade immunotherapy is favoured by the presence of a local, CD8+ T cell-based immune response within the tumour microenvironment. As molecular analyses of tumours containing or lacking a productive CD8+ T cell infiltrate are being pursued, increasing evidence is indicating that activation of oncogenic pathways in tumour cells can impair induction or execution of a local antitumour immune response. This Review summarizes our current knowledge of the influence of oncogenic effects on evasion of antitumour immunity.
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