Over the last 30 years glucose intolerance has been reported in a significant percentage of
patients with amyotrophic lateral sclerosis (ALS). Currently, a controversy exists in
determining whether the carbohydrate abnormality is disease-specific or secondary to
decreased glucose utilization due to muscle atrophy. A reduction in glucose receptor space
had been postulated for a number of neuromuscular diseases including ALS. In order to
clarify this issue we have estimated in vivo insulin sensitivity, using the euglycemic insulin …