HIF‐prolyl hydroxylases as therapeutic targets in erythropoiesis and iron metabolism

VH Haase - Hemodialysis international, 2017 - Wiley Online Library
Hemodialysis international, 2017Wiley Online Library
A classic response to systemic hypoxia is the increase in red blood cell production. This
response is controlled by the prolyl hydroxylase domain/hypoxia‐inducible factor (HIF)
pathway, which regulates a broad spectrum of cellular functions. The discovery of this
pathway as a key regulator of erythropoiesis has led to the development of small molecules
that stimulate the production of endogenous erythropoietin and enhance iron metabolism.
This review provides a concise overview of the cellular and molecular mechanisms that …
Abstract
A classic response to systemic hypoxia is the increase in red blood cell production. This response is controlled by the prolyl hydroxylase domain/hypoxia‐inducible factor (HIF) pathway, which regulates a broad spectrum of cellular functions. The discovery of this pathway as a key regulator of erythropoiesis has led to the development of small molecules that stimulate the production of endogenous erythropoietin and enhance iron metabolism. This review provides a concise overview of the cellular and molecular mechanisms that govern HIF‐induced erythropoietic responses and provides an update on clinical experience with compounds that target HIF‐prolyl hydroxylases for anemia therapy.
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