Independent Modes of Natural Killing Distinguished in Mice Lacking Lag3
T Miyazaki, A Dierich, C Benoist, D Mathis - Science, 1996 - science.org
T Miyazaki, A Dierich, C Benoist, D Mathis
Science, 1996•science.orgThe LAG3 protein has several features in common with CD4, suggesting that it may be
important in controlling T cell reactivity. However, mice with a Lag3 null mutation have now
been shown to exhibit a defect in the natural killer cell, rather than the T cell, compartment.
Killing of certain tumor targets by natural killer cells from these mice was inhibited or even
abolished, whereas lysis of cells displaying major histocompatibility complex class I
disparities remained intact. It appears that LAG3 is a receptor or coreceptor that defines …
important in controlling T cell reactivity. However, mice with a Lag3 null mutation have now
been shown to exhibit a defect in the natural killer cell, rather than the T cell, compartment.
Killing of certain tumor targets by natural killer cells from these mice was inhibited or even
abolished, whereas lysis of cells displaying major histocompatibility complex class I
disparities remained intact. It appears that LAG3 is a receptor or coreceptor that defines …
The LAG3 protein has several features in common with CD4, suggesting that it may be important in controlling T cell reactivity. However, mice with a Lag3 null mutation have now been shown to exhibit a defect in the natural killer cell, rather than the T cell, compartment. Killing of certain tumor targets by natural killer cells from these mice was inhibited or even abolished, whereas lysis of cells displaying major histocompatibility complex class I disparities remained intact. It appears that LAG3 is a receptor or coreceptor that defines different modes of natural killing.
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