TLRs control hematopoiesis during infection

A Yáñez, HS Goodridge, D Gozalbo… - European journal of …, 2013 - Wiley Online Library
A Yáñez, HS Goodridge, D Gozalbo, ML Gil
European journal of immunology, 2013Wiley Online Library
Recent research has shown that (i) Toll‐like receptor (TLR) agonists drive hematopoietic
stem and progenitor cells (HSPCs) to proliferate and differentiate along the myeloid lineage
in vitro, and (ii) direct TLR‐mediated stimulation of HSPCs also promotes macrophage
differentiation in vivo following infection. These new insights demonstrate that TLR signaling
in HSPCs, in addition to other TLR‐dependent mechanisms, can contribute to HSPC
expansion and myeloid differentiation after infection. Evidence is, therefore, mounting that …
Recent research has shown that (i) Toll‐like receptor (TLR) agonists drive hematopoietic stem and progenitor cells (HSPCs) to proliferate and differentiate along the myeloid lineage in vitro, and (ii) direct TLR‐mediated stimulation of HSPCs also promotes macrophage differentiation in vivo following infection. These new insights demonstrate that TLR signaling in HSPCs, in addition to other TLR‐dependent mechanisms, can contribute to HSPC expansion and myeloid differentiation after infection. Evidence is, therefore, mounting that direct TLR‐induced programming of hematopoiesis plays a key role in host defense by rapidly replenishing the innate immune system with the cells needed to deal with pathogens.
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