Porocarcinomas harbor recurrent HRAS-activating mutations and tumor suppressor inactivating mutations
PW Harms, DH Hovelson, AK Cani, K Omata, MJ Haller… - Human pathology, 2016 - Elsevier
Porocarcinomas are a rare eccrine carcinoma with significant metastatic potential.
Oncogenic drivers of porocarcinomas have been underexplored, with PIK3CA-activating
mutation reported in 1 case. We analyzed 5 porocarcinomas by next-generation sequencing
using the DNA component of the Oncomine Comprehensive Assay, which provides data on
copy number changes and mutational events in 126 cancer-relevant genes through
multiplex polymerase chain reaction. We detected an average of 3.3 high-confidence …
Oncogenic drivers of porocarcinomas have been underexplored, with PIK3CA-activating
mutation reported in 1 case. We analyzed 5 porocarcinomas by next-generation sequencing
using the DNA component of the Oncomine Comprehensive Assay, which provides data on
copy number changes and mutational events in 126 cancer-relevant genes through
multiplex polymerase chain reaction. We detected an average of 3.3 high-confidence …