K-cells and glucose-dependent insulinotropic polypeptide in health and disease
YM Cho, TJ Kieffer - Vitamins & Hormones, 2010 - Elsevier
In the 1970s, glucose-dependent insulinotropic polypeptide (GIP, formerly gastric inhibitory
polypeptide), a 42-amino acid peptide hormone, was discovered through a search for
enterogastrones and subsequently identified as an incretin, or an insulinotropic hormone
secreted in response to intraluminal nutrients. Independent of the discovery of GIP, the K-cell
was identified in small intestine by characteristic ultrastructural features. Subsequently, it
was realized that K-cells are the predominant source of circulating GIP. The density of K …
polypeptide), a 42-amino acid peptide hormone, was discovered through a search for
enterogastrones and subsequently identified as an incretin, or an insulinotropic hormone
secreted in response to intraluminal nutrients. Independent of the discovery of GIP, the K-cell
was identified in small intestine by characteristic ultrastructural features. Subsequently, it
was realized that K-cells are the predominant source of circulating GIP. The density of K …