[HTML][HTML] Structural and pharmacological characterization of novel potent and selective monoclonal antibody antagonists of glucose-dependent insulinotropic …

P Ravn, C Madhurantakam, S Kunze… - Journal of Biological …, 2013 - ASBMB
Glucose-dependent insulinotropic polypeptide (GIP) is an endogenous hormonal factor
(incretin) that, upon binding to its receptor (GIPr; a class B G-protein-coupled receptor),
stimulates insulin secretion by beta cells in the pancreas. There has been a lack of potent
inhibitors of the GIPr with prolonged in vivo exposure to support studies on GIP biology.
Here we describe the generation of an antagonizing antibody to the GIPr, using phage and
ribosome display libraries. Gipg013 is a specific competitive antagonist with equally high …