Eosinophil and neutrophil extracellular DNA traps in human allergic asthmatic airways
R Dworski, HU Simon, A Hoskins, S Yousefi - Journal of Allergy and …, 2011 - Elsevier
BACKGROUND: Asthma is a heterogeneous inflammatory airway disorder that involves
eosinophilic and noneosinophilic phenotypes. Unlike in healthy lungs, eosinophils are often
present in atopic asthmatic airways, although a subpopulation of asthmatic subjects
predominantly experience neutrophilic inflammation. Recently, it has been demonstrated
that eosinophils and neutrophils generate bactericidal extracellular traps consisting of DNA
and cytotoxic granule proteins. OBJECTIVE: We sought to explore whether living …
eosinophilic and noneosinophilic phenotypes. Unlike in healthy lungs, eosinophils are often
present in atopic asthmatic airways, although a subpopulation of asthmatic subjects
predominantly experience neutrophilic inflammation. Recently, it has been demonstrated
that eosinophils and neutrophils generate bactericidal extracellular traps consisting of DNA
and cytotoxic granule proteins. OBJECTIVE: We sought to explore whether living …
