Redox cycling of the herbicide paraquat in microglial cultures
D Bonneh-Barkay, SH Reaney, WJ Langston… - Molecular brain …, 2005 - Elsevier
Mechanisms involved in paraquat neurotoxicity that selectively target nigrostriatal
dopaminergic neurons remain relatively unknown. In this study, we tested the hypotheses
that paraquat exposure leads to the production of reactive oxygen species (ROS) through a
process of redox cycling and that microglia represent an important site for the initiation of
redox cycling reactions. Addition of paraquat to N9 microglial cultures resulted in a dose-and
time-dependent release of superoxide radicals. Other agents that share with paraquat the …
dopaminergic neurons remain relatively unknown. In this study, we tested the hypotheses
that paraquat exposure leads to the production of reactive oxygen species (ROS) through a
process of redox cycling and that microglia represent an important site for the initiation of
redox cycling reactions. Addition of paraquat to N9 microglial cultures resulted in a dose-and
time-dependent release of superoxide radicals. Other agents that share with paraquat the …