Arrestins in metabolic regulation

J Zhao, G Pei - Progress in Molecular Biology and Translational …, 2013 - Elsevier
This review summarizes the regulatory roles of β-arrestins in whole-body energy balance,
body weight control, and carbohydrate and lipid homeostasis. Much research has pointed in
the direction of the functions of β-arrestins in mediating desensitization and endocytosis of G
protein-coupled receptors as well as in activating the receptor/β-arrestin/ERK signaling
pathway being crucial for metabolic regulation. Furthermore, β-arrestins form diverse signal
complexes for the activation of the downstream cassettes for the body's metabolic reactions …