[HTML][HTML] The ubiquitin-conjugating enzyme UbcM2 can regulate the stability and activity of the antioxidant transcription factor Nrf2

KS Plafker, L Nguyen, M Barneche, S Mirza… - Journal of biological …, 2010 - ASBMB
The transcription factor nuclear factor E2-related factor 2 (Nrf2) induces the expression of
antioxidant gene products that neutralize reactive oxygen species and restore redox
homeostasis. Nrf2 is constitutively degraded by the ubiquitin proteolytic system in
unperturbed cells, but this turnover is arrested in response to oxidative stress, thereby
leading to Nrf2 accumulation. Yet, a mechanistic understanding of how Nrf2 stabilization and
transcriptional activation are coupled remains to be determined. We have discovered that …