[HTML][HTML] The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress

T Nguyen, P Nioi, CB Pickett - Journal of biological chemistry, 2009 - ASBMB
A major mechanism in the cellular defense against oxidative or electrophilic stress is
activation of the Nrf2-antioxidant response element signaling pathway, which controls the
expression of genes whose protein products are involved in the detoxication and elimination
of reactive oxidants and electrophilic agents through conjugative reactions and by
enhancing cellular antioxidant capacity. At the molecular level, however, the regulatory
mechanisms involved in mediating Nrf2 activation are not fully understood. It is well …