[HTML][HTML] Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene …
Keap1 is a negative regulator of Nrf2, a bZIP transcription factor that mediates adaptation to
oxidative stress. Previous studies suggested this negative regulation is a consequence of
Keap1 controlling the subcellular distribution of Nrf2. We now report that Keap1 also controls
the total cellular level of Nrf2 protein. In the RL34 non-transformed rat liver cell line, Nrf2 was
found to accumulate rapidly in response to oxidative stress caused by treatment with
sulforaphane, and the accumulation resulted from inhibition of proteasomal-mediated …
oxidative stress. Previous studies suggested this negative regulation is a consequence of
Keap1 controlling the subcellular distribution of Nrf2. We now report that Keap1 also controls
the total cellular level of Nrf2 protein. In the RL34 non-transformed rat liver cell line, Nrf2 was
found to accumulate rapidly in response to oxidative stress caused by treatment with
sulforaphane, and the accumulation resulted from inhibition of proteasomal-mediated …