Macrophages play a crucial role in regeneration and consecutive phases of wound healing.
In this review, we summarise current knowledge on the ontogeny, origin, phenotypical
heterogeneity, and functional exchangeability of macrophages participating in these
processes. We also describe the genetic, pharmacologic, and bioengineering methods for
manipulation of macrophage phenotype and functions and their potential for development of
the novel, clinically applicable therapies.