Metabolic shifts in immunity and inflammation

DJ Kominsky, EL Campbell… - The Journal of Immunology, 2010 - journals.aai.org
DJ Kominsky, EL Campbell, SP Colgan
The Journal of Immunology, 2010journals.aai.org
Sites of ongoing inflammation and triggered immune responses are characterized by
significant changes in metabolic activity. Recent studies have indicated that such shifts in
tissue metabolism result from a combination of profound recruitment of inflammatory cells
(neutrophils and monocytes) and high proliferation rates among lymphocyte populations.
The resultant shifts in energy supply and demand can result in metabolic acidosis and
diminished delivery and/or availability of oxygen, leading to hypoxia extensive enough to …
Abstract
Sites of ongoing inflammation and triggered immune responses are characterized by significant changes in metabolic activity. Recent studies have indicated that such shifts in tissue metabolism result from a combination of profound recruitment of inflammatory cells (neutrophils and monocytes) and high proliferation rates among lymphocyte populations. The resultant shifts in energy supply and demand can result in metabolic acidosis and diminished delivery and/or availability of oxygen, leading to hypoxia extensive enough to trigger transcriptional and translation changes in tissue phenotype. Such phenotypic shifts can imprint fundamental changes to tissue metabolism. In this study, we review recent work addressing metabolic changes and metabolic control of inflammation and immunity.
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