[HTML][HTML] Human skin dendritic cells in health and disease

M Haniffa, M Gunawan, L Jardine - Journal of dermatological science, 2015 - Elsevier
Dendritic cells (DCs) are specialized antigen presenting cells abundant in peripheral tissues
such as skin where they function as immune sentinels. Skin DCs migrate to draining lymph
node where they interact with naïve T cells to induce immune responses to microorganisms,
vaccines, tumours and self-antigens. In this review, we present the key historical
developments and recent advances in human skin DC research. We also integrate the
current understanding on the origin and functional specializations of DC subsets in healthy …