Identification of tumor necrosis factor-α (TNFα) as the key agent in inflammatory disorders,
eg rheumatoid arthritis, Crohn's disease, and psoriasis, led to TNFα-targeting therapies,
which, although avoiding many of the side-effects of previous drugs, nonetheless causes
other side-effects, including secondary infections and cancer. By controlling gene
expression, TNFα orchestrates the cutaneous responses to environmental damage and
inflammation. To define TNFα action in epidermis, we compared the transcriptional profiles …