Macrophage heme oxygenase-1-SIRT1-p53 axis regulates sterile inflammation in liver ischemia-reperfusion injury

K Nakamura, M Zhang, S Kageyama, B Ke, T Fujii… - Journal of …, 2017 - Elsevier
Background & Aims Hepatic ischemia-reperfusion injury (IRI), characterized by exogenous
antigen-independent local inflammation and hepatocellular death, represents a risk factor
for acute and chronic rejection in liver transplantation. We aimed to investigate the molecular
communication involved in the mechanism of liver IRI. Methods We analyzed human liver
transplants, primary murine macrophage cell cultures and IR-stressed livers in myeloid-
specific heme oxygenase-1 (HO-1) gene mutant mice, for anti-inflammatory and …