[HTML][HTML] Heme oxygenase-1 regulates sirtuin-1–autophagy pathway in liver transplantation: From mouse to human

K Nakamura, S Kageyama, S Yue, J Huang… - American Journal of …, 2018 - Elsevier
Liver ischemia–reperfusion injury (IRI) represents a major risk factor of early graft
dysfunction and a key obstacle to expanding the donor pool in orthotopic liver
transplantation (OLT). Although graft autophagy is essential for resistance against hepatic
IRI, its significance in clinical OLT remains unknown. Despite recent data identifying heme
oxygenase-1 (HO-1) as a putative autophagy inducer, its role in OLT and interactions with
sirtuin-1 (SIRT1), a key autophagy regulator, have not been studied. We aimed to examine …