[HTML][HTML] The double bromodomain-containing chromatin adaptor Brd4 and transcriptional regulation
SY Wu, CM Chiang - Journal of Biological Chemistry, 2007 - ASBMB
Brd4 is a double bromodomain-containing protein that binds preferentially to acetylated
chromatin. It belongs to the BET (bromodomains and extraterminal) family that includes
mammalian Brd2, Brd3, Brd4, Brdt, Drosophila Fsh, yeast Bdf1, Bdf2, and corresponding
homologues in other species. Brd4 is essential for cellular growth and has been implicated
in cell cycle control, DNA replication, and gene rearrangement found in t (15; 19)-associated
carcinomas. Recently, Brd4 has been found in several transcription complexes, including …
chromatin. It belongs to the BET (bromodomains and extraterminal) family that includes
mammalian Brd2, Brd3, Brd4, Brdt, Drosophila Fsh, yeast Bdf1, Bdf2, and corresponding
homologues in other species. Brd4 is essential for cellular growth and has been implicated
in cell cycle control, DNA replication, and gene rearrangement found in t (15; 19)-associated
carcinomas. Recently, Brd4 has been found in several transcription complexes, including …