[HTML][HTML] Macrophages are critical to the maintenance of IL-13-dependent lung inflammation and fibrosis
The roles of macrophages in type 2-driven inflammation and fibrosis remain unclear. Here,
using CD11b-diphtheria toxin receptor (DTR) transgenic mice and three models of
interleukin 13 (IL-13)-dependent inflammation, fibrosis, and immunity, we show that CD11b+
F4/80+ Ly6C+ macrophages are required for the maintenance of type 2 immunity within
affected tissues but not secondary lymphoid organs. Direct depletion of macrophages during
the maintenance or resolution phases of secondary Schistosoma mansoni egg-induced …
using CD11b-diphtheria toxin receptor (DTR) transgenic mice and three models of
interleukin 13 (IL-13)-dependent inflammation, fibrosis, and immunity, we show that CD11b+
F4/80+ Ly6C+ macrophages are required for the maintenance of type 2 immunity within
affected tissues but not secondary lymphoid organs. Direct depletion of macrophages during
the maintenance or resolution phases of secondary Schistosoma mansoni egg-induced …