Roles of basigin, a member of the immunoglobulin superfamily, in behavior as to an irritating odor, lymphocyte response, and blood–brain barrier
T Igakura, K Kadomatsu, O Taguchi… - Biochemical and …, 1996 - Elsevier
T Igakura, K Kadomatsu, O Taguchi, H Muramatsu, T Kaname, T Miyauchi, K Yamamura…
Biochemical and biophysical research communications, 1996•ElsevierBasigin is a transmembrane glycoprotein belonging to the immunoglobulin superfamily.
Using the knockout mouse lacking the basigin gene (Bsg), we analyzed the function of
basigin in adult mice lacking the gene [Bsg (-/-)]. Although histochemical studies on the
localization of basigin (also called HT7 and neurothelin) strongly indicated that it is involved
in the function of the blood–brain barrier, basigin knockout mice showed only a little
difference, if any, to wild-type mice in the function of the blood brain–barrier. The mitogenic …
Using the knockout mouse lacking the basigin gene (Bsg), we analyzed the function of
basigin in adult mice lacking the gene [Bsg (-/-)]. Although histochemical studies on the
localization of basigin (also called HT7 and neurothelin) strongly indicated that it is involved
in the function of the blood–brain barrier, basigin knockout mice showed only a little
difference, if any, to wild-type mice in the function of the blood brain–barrier. The mitogenic …
Basigin is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. Using the knockout mouse lacking the basigin gene (Bsg), we analyzed the function of basigin in adult mice lacking the gene [Bsg(-/-)]. Although histochemical studies on the localization of basigin (also called HT7 and neurothelin) strongly indicated that it is involved in the function of the blood–brain barrier, basigin knockout mice showed only a little difference, if any, to wild-type mice in the function of the blood brain–barrier. The mitogenic response of lymphocytes upon mixed lymphocyte reaction was greater inBsg(-/-) mice. Finally,Bsg(-/-) mice repeatedly visited filter paper impregnated with acetic acid or isozine, indicating an abnormality in either reception of the odor or behavior as to it.
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