Alterations in junctional proteins, inflammatory mediators and extracellular matrix molecules in eosinophilic esophagitis
SM Abdulnour-Nakhoul, Y Al-Tawil, AA Gyftopoulos… - Clinical …, 2013 - Elsevier
Eosinophilic esophagitis (EoE), an inflammatory atopic disease of the esophagus, causes
massive eosinophil infiltration, basal cell hyperplasia, and sub-epithelial fibrosis. To
elucidate cellular and molecular factors involved in esophageal tissue damage and
remodeling, we examined pinch biopsies from EoE and normal pediatric patients. An
inflammation gene array confirmed that eotaxin-3, its receptor CCR3 and interleukins IL-13
and IL-5 were upregulated. An extracellular matrix (ECM) gene array revealed upregulation …
massive eosinophil infiltration, basal cell hyperplasia, and sub-epithelial fibrosis. To
elucidate cellular and molecular factors involved in esophageal tissue damage and
remodeling, we examined pinch biopsies from EoE and normal pediatric patients. An
inflammation gene array confirmed that eotaxin-3, its receptor CCR3 and interleukins IL-13
and IL-5 were upregulated. An extracellular matrix (ECM) gene array revealed upregulation …