[HTML][HTML] Hypoxia and mitochondrial inhibitors regulate expression of glucose transporter-1 via distinct Cis-acting sequences
BL Ebert, JD Firth, PJ Ratcliffe - Journal of Biological Chemistry, 1995 - ASBMB
Studies of gene regulation by oxygen have recently defined the existence of a widely
operative system that responds to hypoxia but not mitochondrial inhibitors and involves the
induction of a DNA-binding complex termed hypoxia-inducible factor 1. This system has
been implicated in the regulation of erythropoietin, certain angiogenic growth factors, and
particular glycolytic isoenzymes. The glucose transporter Glut-1 is induced by both hypoxia
and mitochondrial inhibitors, implying the operation of a different mechanism of oxygen …
operative system that responds to hypoxia but not mitochondrial inhibitors and involves the
induction of a DNA-binding complex termed hypoxia-inducible factor 1. This system has
been implicated in the regulation of erythropoietin, certain angiogenic growth factors, and
particular glycolytic isoenzymes. The glucose transporter Glut-1 is induced by both hypoxia
and mitochondrial inhibitors, implying the operation of a different mechanism of oxygen …