[HTML][HTML] AKAP79 interacts with multiple adenylyl cyclase (AC) isoforms and scaffolds AC5 and-6 to α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA) …
R Efendiev, BK Samelson, BT Nguyen… - Journal of biological …, 2010 - ASBMB
Spatiotemporal specificity of cAMP action is best explained by targeting protein kinase A
(PKA) to its substrates by A-kinase-anchoring proteins (AKAPs). At synapses in the brain,
AKAP79/150 incorporates PKA and other regulatory enzymes into signal transduction
networks that include β-adrenergic receptors, α-amino-3-hydroxyl-5-methyl-4-isoxazole-
propionate (AMPA), and N-methyl-d-aspartic acid receptors. We previously showed that
AKAP79/150 clusters PKA with type 5 adenylyl cyclase (AC5) to assemble a negative …
(PKA) to its substrates by A-kinase-anchoring proteins (AKAPs). At synapses in the brain,
AKAP79/150 incorporates PKA and other regulatory enzymes into signal transduction
networks that include β-adrenergic receptors, α-amino-3-hydroxyl-5-methyl-4-isoxazole-
propionate (AMPA), and N-methyl-d-aspartic acid receptors. We previously showed that
AKAP79/150 clusters PKA with type 5 adenylyl cyclase (AC5) to assemble a negative …