[HTML][HTML] Selective down-regulation of KV2. 1 function contributes to enhanced arterial tone during diabetes
M Nieves-Cintrón, MA Nystoriak, MP Prada… - Journal of Biological …, 2015 - ASBMB
Enhanced arterial tone is a leading cause of vascular complications during diabetes.
Voltage-gated K+(KV) channels are key regulators of vascular smooth muscle cells (VSMCs)
contractility and arterial tone. Whether impaired KV channel function contributes to enhance
arterial tone during diabetes is unclear. Here, we demonstrate a reduction in K V-mediated
currents (I Kv) in VSMCs from a high fat diet (HFD) mouse model of type 2 diabetes. In
particular, I Kv sensitive to stromatoxin (ScTx), a potent KV 2 blocker, were selectively …
Voltage-gated K+(KV) channels are key regulators of vascular smooth muscle cells (VSMCs)
contractility and arterial tone. Whether impaired KV channel function contributes to enhance
arterial tone during diabetes is unclear. Here, we demonstrate a reduction in K V-mediated
currents (I Kv) in VSMCs from a high fat diet (HFD) mouse model of type 2 diabetes. In
particular, I Kv sensitive to stromatoxin (ScTx), a potent KV 2 blocker, were selectively …