[HTML][HTML] Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action
V Aguirre, ED Werner, J Giraud, YH Lee… - Journal of Biological …, 2002 - ASBMB
Serine phosphorylation of insulin receptor substrate-1 (IRS-1) inhibits insulin signal
transduction in a variety of cell backgrounds, which might contribute to peripheral insulin
resistance. However, because of the large number of potential phosphorylation sites, the
mechanism of inhibition has been difficult to determine. One serine residue located near the
phosphotyrosine-binding (PTB) domain in IRS-1 (Ser 307 in rat IRS-1 or Ser 312 in human
IRS-1) is phosphorylated via several mechanisms, including insulin-stimulated kinases or …
transduction in a variety of cell backgrounds, which might contribute to peripheral insulin
resistance. However, because of the large number of potential phosphorylation sites, the
mechanism of inhibition has been difficult to determine. One serine residue located near the
phosphotyrosine-binding (PTB) domain in IRS-1 (Ser 307 in rat IRS-1 or Ser 312 in human
IRS-1) is phosphorylated via several mechanisms, including insulin-stimulated kinases or …