The role of the osteocyte in bone and nonbone disease

LF Bonewald - Endocrinology and Metabolism Clinics, 2017 - endo.theclinics.com
Before osteocytes were recognized as active essential bone cells necessary for bone health,
it was assumed that all the action took place on the bone surface and not within the bone.
Osteoblasts and osteoclasts were the major players, osteoblasts making bone and
osteoclasts resorbing bone to maintain bone homeostasis. It was assumed that osteoblasts
and osteoclasts were regulated by external factors such as parathyroid hormone (PTH) or 1,
25 dihydroxyvitamin D3, and other external regulatory factors. It has also been proposed that …