[HTML][HTML] Transplanting hepatitis C virus–infected hearts into uninfected recipients: a single-arm trial

RC McLean, PP Reese, M Acker, P Atluri… - American Journal of …, 2019 - Elsevier
The advent of direct-acting antiviral therapy for hepatitis C virus (HCV) has generated
tremendous interest in transplanting organs from HCV-infected donors. We conducted a
single-arm trial of orthotopic heart transplantation (OHT) from HCV-infected donors into
uninfected recipients, followed by elbasvir/grazoprevir treatment after recipient HCV was first
detected (NCT03146741; sponsor: Merck). We enrolled OHT candidates aged 40-65 years;
left ventricular assist device (LVAD) support and liver disease were exclusions. We accepted …