[HTML][HTML] c-Myc is glycosylated at threonine 58, a known phosphorylation site and a mutational hot spot in lymphomas
c-Myc is a helix-loop-helix leucine zipper phosphoprotein that heterodimerizes with Max and
regulates gene transcription in cell proliferation, cell differentiation, and programmed cell
death. Previously, we demonstrated that c-Myc is modified by O-linked N-acetylglucosamine
(O-GlcNAc) within or nearby the N-terminal transcriptional activation domain (Chou, T.-Y.,
Dang, CV, and Hart, GW (1995) Proc. Natl. Acad. Sci. USA 92, 4417-4421). In this paper, we
identified the O-GlcNAc attachment site (s) on c-Myc. c-Myc purified from sf9 insect cells was …
regulates gene transcription in cell proliferation, cell differentiation, and programmed cell
death. Previously, we demonstrated that c-Myc is modified by O-linked N-acetylglucosamine
(O-GlcNAc) within or nearby the N-terminal transcriptional activation domain (Chou, T.-Y.,
Dang, CV, and Hart, GW (1995) Proc. Natl. Acad. Sci. USA 92, 4417-4421). In this paper, we
identified the O-GlcNAc attachment site (s) on c-Myc. c-Myc purified from sf9 insect cells was …