[HTML][HTML] The mechanoenzymatic core of dynamin-related protein 1 comprises the minimal machinery required for membrane constriction
CA Francy, FJD Alvarez, L Zhou… - Journal of Biological …, 2015 - ASBMB
Mitochondria are dynamic organelles that continually undergo cycles of fission and fusion.
Dynamin-related protein 1 (Drp1), a large GTPase of the dynamin superfamily, is the main
mediator of mitochondrial fission. Like prototypical dynamin, Drp1 is composed of a
mechanochemical core consisting of the GTPase, middle, and GTPase effector domain
regions. In place of the pleckstrin homology domain in dynamin, however, Drp1 contains an
unstructured variable domain, whose function is not yet fully resolved. Here, using time …
Dynamin-related protein 1 (Drp1), a large GTPase of the dynamin superfamily, is the main
mediator of mitochondrial fission. Like prototypical dynamin, Drp1 is composed of a
mechanochemical core consisting of the GTPase, middle, and GTPase effector domain
regions. In place of the pleckstrin homology domain in dynamin, however, Drp1 contains an
unstructured variable domain, whose function is not yet fully resolved. Here, using time …