[HTML][HTML] LPA1 receptor–mediated thromboxane A2 release is responsible for lysophosphatidic acid-induced vascular smooth muscle contraction
PT Dancs, É Ruisanchez, A Balogh, CR Panta… - The FASEB …, 2017 - ncbi.nlm.nih.gov
The FASEB Journal, 2017•ncbi.nlm.nih.gov
Lysophosphatidic acid (LPA) has been recognized recently as an endothelium-dependent
vasodilator, but several lines of evidence indicate that it may also stimulate vascular smooth
muscle cells (VSMCs), thereby contributing to vasoregulation and remodeling. In the present
study, mRNA expression of all 6 LPA receptor genes was detected in murine aortic VSMCs,
with the highest levels of LPA 1, LPA 2, LPA 4, and LPA 6. In endothelium-denuded thoracic
aorta (TA) and abdominal aorta (AA) segments, 1-oleoyl-LPA and the LPA 1–3 agonist
vasodilator, but several lines of evidence indicate that it may also stimulate vascular smooth
muscle cells (VSMCs), thereby contributing to vasoregulation and remodeling. In the present
study, mRNA expression of all 6 LPA receptor genes was detected in murine aortic VSMCs,
with the highest levels of LPA 1, LPA 2, LPA 4, and LPA 6. In endothelium-denuded thoracic
aorta (TA) and abdominal aorta (AA) segments, 1-oleoyl-LPA and the LPA 1–3 agonist
Abstract
Lysophosphatidic acid (LPA) has been recognized recently as an endothelium-dependent vasodilator, but several lines of evidence indicate that it may also stimulate vascular smooth muscle cells (VSMCs), thereby contributing to vasoregulation and remodeling. In the present study, mRNA expression of all 6 LPA receptor genes was detected in murine aortic VSMCs, with the highest levels of LPA 1, LPA 2, LPA 4, and LPA 6. In endothelium-denuded thoracic aorta (TA) and abdominal aorta (AA) segments, 1-oleoyl-LPA and the LPA 1–3 agonist
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