Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs
CJ March, B Mosley, A Larsen, DP Cerretti, G Braedt… - Nature, 1985 - nature.com
CJ March, B Mosley, A Larsen, DP Cerretti, G Braedt, V Price, S Gillis, CS Henney…
Nature, 1985•nature.comTwo distinct but distantly related complementary DNAs encoding proteins sharing human
interleukin-1 (IL-1) activity (termed IL-lα and IL-1β), were isolated from a macrophage cDNA
library. The primary translation products of the genes are 271 and 269 amino acids long,
although expression in Escherichia coli of the carboxy-terminal 159 and 153 amino acids
produces IL-1 biological activity.
interleukin-1 (IL-1) activity (termed IL-lα and IL-1β), were isolated from a macrophage cDNA
library. The primary translation products of the genes are 271 and 269 amino acids long,
although expression in Escherichia coli of the carboxy-terminal 159 and 153 amino acids
produces IL-1 biological activity.
Abstract
Two distinct but distantly related complementary DNAs encoding proteins sharing human interleukin-1 (IL-1) activity (termed IL-lα and IL-1β), were isolated from a macrophage cDNA library. The primary translation products of the genes are 271 and 269 amino acids long, although expression in Escherichia coli of the carboxy-terminal 159 and 153 amino acids produces IL-1 biological activity.
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