[HTML][HTML] Desmoglein 2, but not desmocollin 2, protects intestinal epithelia from injury
A Gross, LAP Pack, GM Schacht, S Kant… - Mucosal …, 2018 - Elsevier
Desmosomes are the least understood intercellular junctions in the intestinal epithelia and
provide cell–cell adhesion via the cadherins desmoglein (Dsg) 2 and desmocollin (Dsc) 2.
We studied these cadherins in Crohn's disease (CD) patients and in newly generated
conditional villin-Cre DSG2 and DSC2 knockout mice (DSG2 ΔIEC; DSC2 ΔIEC). CD
patients exhibited altered desmosomes and reduced Dsg2/Dsc2 levels. The intestines of
both transgenic animal lines were histopathologically inconspicuous. However, DSG2 ΔIEC …
provide cell–cell adhesion via the cadherins desmoglein (Dsg) 2 and desmocollin (Dsc) 2.
We studied these cadherins in Crohn's disease (CD) patients and in newly generated
conditional villin-Cre DSG2 and DSC2 knockout mice (DSG2 ΔIEC; DSC2 ΔIEC). CD
patients exhibited altered desmosomes and reduced Dsg2/Dsc2 levels. The intestines of
both transgenic animal lines were histopathologically inconspicuous. However, DSG2 ΔIEC …