[HTML][HTML] Galectin-3 regulates desmoglein-2 and intestinal epithelial intercellular adhesion
The desmosomal cadherins, desmogleins, and desmocollins mediate strong intercellular
adhesion. Human intestinal epithelial cells express the desmoglein-2 isoform. A proteomic
screen for Dsg2-associated proteins in intestinal epithelial cells identified a lectin referred to
as galectin-3 (Gal3). Gal3 bound to N-linked β-galactosides in Dsg2 extracellular domain
and co-sedimented with caveolin-1 in lipid rafts. Down-regulation of Gal3 protein or
incubation with lactose, a galactose-containing disaccharide that competitively inhibits …
adhesion. Human intestinal epithelial cells express the desmoglein-2 isoform. A proteomic
screen for Dsg2-associated proteins in intestinal epithelial cells identified a lectin referred to
as galectin-3 (Gal3). Gal3 bound to N-linked β-galactosides in Dsg2 extracellular domain
and co-sedimented with caveolin-1 in lipid rafts. Down-regulation of Gal3 protein or
incubation with lactose, a galactose-containing disaccharide that competitively inhibits …