Interleukin-1β activates a MYC-dependent metabolic switch in kidney stromal cells necessary for progressive tubulointerstitial fibrosis
DR Lemos, M McMurdo, G Karaca… - Journal of the …, 2018 - journals.lww.com
Background Kidney injury is characterized by persisting inflammation and fibrosis, yet
mechanisms by which inflammatory signals drive fibrogenesis remain poorly defined.
Methods RNA sequencing of fibrotic kidneys from patients with CKD identified a metabolic
gene signature comprising loss of mitochondrial and oxidative phosphorylation gene
expression with a concomitant increase in regulators and enzymes of glycolysis under the
control of PGC1α and MYC transcription factors, respectively. We modeled this metabolic …
mechanisms by which inflammatory signals drive fibrogenesis remain poorly defined.
Methods RNA sequencing of fibrotic kidneys from patients with CKD identified a metabolic
gene signature comprising loss of mitochondrial and oxidative phosphorylation gene
expression with a concomitant increase in regulators and enzymes of glycolysis under the
control of PGC1α and MYC transcription factors, respectively. We modeled this metabolic …