Early goal-directed therapy for severe sepsis and septic shock: A living systematic review
SQ Simpson, M Gaines, Y Hussein, RG Badgett - Journal of critical care, 2016 - Elsevier
Studies and meta-analyses conflict regarding the use of early goal-directed therapy (EGDT)
for septic shock. We sought to clarify the conflict by performing a living systematic review and
meta-regression. Methods We performed a meta-analysis and explored heterogeneity with
meta-regression. We conformed with the Preferred Reporting Items for Systematic Reviews
and Meta-Analyses checklist and qualified strength of evidence with a Grading of
Recommendations Assessment, Development and Evaluation profile. Results Overall …
for septic shock. We sought to clarify the conflict by performing a living systematic review and
meta-regression. Methods We performed a meta-analysis and explored heterogeneity with
meta-regression. We conformed with the Preferred Reporting Items for Systematic Reviews
and Meta-Analyses checklist and qualified strength of evidence with a Grading of
Recommendations Assessment, Development and Evaluation profile. Results Overall …