[HTML][HTML] Extracellular human thioredoxin-1 inhibits lipopolysaccharide-induced interleukin-1β expression in human monocyte-derived macrophages

L Billiet, C Furman, G Larigauderie, C Copin… - Journal of Biological …, 2005 - ASBMB
Oxidative stress plays an important role in atherosclerotic vascular disease, and several
recent studies were focused on thioredoxin-1 (Trx-1) and its potential protective role against
oxidative stress. Since human monocyte-derived macrophages (HMDM) are important cells
in several inflammatory diseases including atherosclerosis, we conducted this study to
evaluate the impact of extracellular recombinant human Trx-1 (rhTrx-1) on gene expression
in lipopolysaccharide-activated HMDM. Our results showed that rhTrx-1 was capable of …