Viral clearance without destruction of infected cells during acute HBV infection
LG Guidotti, R Rochford, J Chung, M Shapiro, R Purcell… - Science, 1999 - science.org
LG Guidotti, R Rochford, J Chung, M Shapiro, R Purcell, FV Chisari
Science, 1999•science.orgViral clearance during hepatitis B virus (HBV) infection has been thought to reflect the
destruction of infected hepatocytes by CD8+ T lymphocytes. However, in this study, HBV
DNA was shown to largely disappear from the liver and the blood of acutely infected
chimpanzees long before the peak of T cell infiltration and most of the liver disease. These
results demonstrate that noncytopathic antiviral mechanisms contribute to viral clearance
during acute viral hepatitis by purging HBV replicative intermediates from the cytoplasm and …
destruction of infected hepatocytes by CD8+ T lymphocytes. However, in this study, HBV
DNA was shown to largely disappear from the liver and the blood of acutely infected
chimpanzees long before the peak of T cell infiltration and most of the liver disease. These
results demonstrate that noncytopathic antiviral mechanisms contribute to viral clearance
during acute viral hepatitis by purging HBV replicative intermediates from the cytoplasm and …
Viral clearance during hepatitis B virus (HBV) infection has been thought to reflect the destruction of infected hepatocytes by CD8+ T lymphocytes. However, in this study, HBV DNA was shown to largely disappear from the liver and the blood of acutely infected chimpanzees long before the peak of T cell infiltration and most of the liver disease. These results demonstrate that noncytopathic antiviral mechanisms contribute to viral clearance during acute viral hepatitis by purging HBV replicative intermediates from the cytoplasm and covalently closed circular viral DNA from the nucleus of infected cells.
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