Hepatitis Delta co-infection in humanized mice leads to pronounced induction of innate immune responses in comparison to HBV mono-infection
K Giersch, L Allweiss, T Volz, M Helbig, J Bierwolf… - Journal of …, 2015 - Elsevier
Background & Aims The limited availability of hepatitis Delta virus (HDV) infection models
has hindered studies of interactions between HDV and infected hepatocytes. The aim was to
investigate the antiviral state of HDV infected human hepatocytes in the setting of co-
infection with hepatitis B virus (HBV) compared to HBV mono-infection using human liver
chimeric mice. Methods Viral loads, human interferon stimulated genes (hISGs) and
cytokines were determined in humanized uPA/SCID/beige (USB) mice by qRT-PCR, ELISA …
has hindered studies of interactions between HDV and infected hepatocytes. The aim was to
investigate the antiviral state of HDV infected human hepatocytes in the setting of co-
infection with hepatitis B virus (HBV) compared to HBV mono-infection using human liver
chimeric mice. Methods Viral loads, human interferon stimulated genes (hISGs) and
cytokines were determined in humanized uPA/SCID/beige (USB) mice by qRT-PCR, ELISA …