Prevalence and heterogeneity of circulating tumour cells in metastatic cutaneous melanoma
L Khoja, P Shenjere, C Hodgson, J Hodgetts… - Melanoma …, 2014 - journals.lww.com
We previously demonstrated that circulating tumour cells (CTCs) are detectable by the
MelCAM and high molecular weight melanoma-associated antigen (HMW-MAA)-dependent
CellSearch platform. However, CTCs which do not express these capture and detection
markers are not detectable by CellSearch. Consequently, we explored the use of isolation
by size of epithelial tumour cells (ISET), a marker independent, filtration-based device to
determine the prevalence and heterogeneity of CTCs in metastatic cutaneous melanoma …
MelCAM and high molecular weight melanoma-associated antigen (HMW-MAA)-dependent
CellSearch platform. However, CTCs which do not express these capture and detection
markers are not detectable by CellSearch. Consequently, we explored the use of isolation
by size of epithelial tumour cells (ISET), a marker independent, filtration-based device to
determine the prevalence and heterogeneity of CTCs in metastatic cutaneous melanoma …