Relative hepatotoxicity of 2-(substituted phenyl) thiazoles and substituted thiobenzamides in mice: evidence for the involvement of thiobenzamides as ring cleavage …
T Mizutani, K Suzuki - Toxicology letters, 1996 - Elsevier
The hepatotoxicity of the 3 isomers of para-substituted thiobenzamides and the 3 isomers of
2-(para-substituted phenyl)-4-methylthiazoles was evaluated in mice depleted of glutathione
(GSH) by pretreatment with buthionine sulfoximine (BSO). In accordance with previous
studies with the rat, p-methoxythiobenzamide was more toxic than thiobenzamide, and
conversely p-chlorothiobenzamide was markedly less toxic as assessed by serum alanine
aminotransferase (ALT) activity. The hepatotoxicity of 2-phenyl-4-methylthiazole was also …
2-(para-substituted phenyl)-4-methylthiazoles was evaluated in mice depleted of glutathione
(GSH) by pretreatment with buthionine sulfoximine (BSO). In accordance with previous
studies with the rat, p-methoxythiobenzamide was more toxic than thiobenzamide, and
conversely p-chlorothiobenzamide was markedly less toxic as assessed by serum alanine
aminotransferase (ALT) activity. The hepatotoxicity of 2-phenyl-4-methylthiazole was also …