Abnormalities of the erythrocyte membrane
PG Gallagher - Pediatric Clinics, 2013 - pediatric.theclinics.com
Primary abnormalities of the erythrocyte membrane lead to a variety of clinical syndromes,
including hereditary spherocytosis (HS), hereditary elliptocytosis, and related disorders. 1
Clinical and laboratory manifestations, as well as associated molecular defects, of these
disorders vary widely. Abnormalities of erythrocyte shape on peripheral blood smear often
provide clues to the underlying pathobiology and clinical diagnosis of the underlying
disorder.
including hereditary spherocytosis (HS), hereditary elliptocytosis, and related disorders. 1
Clinical and laboratory manifestations, as well as associated molecular defects, of these
disorders vary widely. Abnormalities of erythrocyte shape on peripheral blood smear often
provide clues to the underlying pathobiology and clinical diagnosis of the underlying
disorder.