[HTML][HTML] Tissue factor–positive tumor microvesicles activate platelets and enhance thrombosis in mice

JE Geddings, Y Hisada, Y Boulaftali, TM Getz… - Journal of thrombosis …, 2016 - Elsevier
Essentials• Cancer patients have a high rate of venous thrombosis (VT) but the underlying
mechanisms are unknown.• Tumor‐derived, tissue factor‐positive microvesicles in platelet
activation in vitro and in vivo were studied.• Tumor‐derived, tissue factor‐positive
microvesicles enhanced VT in mice.• Platelets may contribute to VT in some cancer patients,
and this could be prevented with antiplatelet drugs. Summary: Background Cancer patients
have an approximately 4‐fold increased risk of venous thromboembolism (VTE) compared …