[HTML][HTML] Matrix GLA protein, an inhibitory morphogen in pulmonary vascular development
Deficiency of matrix GLA protein (MGP), an inhibitor of bone morphogenetic protein (BMP)-
2/4, is known to cause arterial calcification and peripheral pulmonary artery stenosis. Yet the
vascular role of MGP remains poorly understood. To further investigate MGP, we created a
new MGP transgenic mouse model with high expression of the transgene in the lungs. The
excess MGP led to a disruption of the pulmonary pattern of BMP-4, and resulted in
significant morphological defects in the pulmonary artery tree. Specifically, the vascular …
2/4, is known to cause arterial calcification and peripheral pulmonary artery stenosis. Yet the
vascular role of MGP remains poorly understood. To further investigate MGP, we created a
new MGP transgenic mouse model with high expression of the transgene in the lungs. The
excess MGP led to a disruption of the pulmonary pattern of BMP-4, and resulted in
significant morphological defects in the pulmonary artery tree. Specifically, the vascular …