Autocrine adenosine signaling promotes regulatory T cell–mediated renal protection
GR Kinsey, L Huang, K Jaworska… - Journal of the …, 2012 - journals.lww.com
Regulatory T cells (Tregs) suppress the innate inflammation associated with kidney
ischemia-reperfusion injury (IRI), but the mechanism is not well understood. Tregs express
CD73, the final enzyme involved in the production of extracellular adenosine, and activation
of the adenosine 2A receptor (A 2A R) on immune cells suppresses inflammation and
preserves kidney function after IRI. We hypothesized that Treg-generated adenosine is
required to block innate immune responses in kidney IRI and that the Treg-generated …
ischemia-reperfusion injury (IRI), but the mechanism is not well understood. Tregs express
CD73, the final enzyme involved in the production of extracellular adenosine, and activation
of the adenosine 2A receptor (A 2A R) on immune cells suppresses inflammation and
preserves kidney function after IRI. We hypothesized that Treg-generated adenosine is
required to block innate immune responses in kidney IRI and that the Treg-generated …
