[HTML][HTML] Identification of Ipaf, a human caspase-1-activating protein related to Apaf-1

JL Poyet, SM Srinivasula, M Tnani, M Razmara… - Journal of Biological …, 2001 - ASBMB
Procaspase-9 contains an NH 2-terminal caspase-associated recruitment domain (CARD),
which is essential for direct association with Apaf-1 and activation. Procaspase-1 also
contains an NH 2-terminal CARD domain, suggesting that its mechanism of activation, like
that of procaspase-9, involves association with an Apaf-1-related molecule. Here we
describe the identification of a human Apaf-1-related protein, named Ipaf that contains an
NH 2-terminal CARD domain, a central nucleotide-binding domain, and a COOH-terminal …