Reduced osteoblastic population and defective mineralization in osteopetrotic (op/op) mice
N Sakagami, N Amizuka, M Li, K Takeuchi, M Hoshino… - Micron, 2005 - Elsevier
Osteopetrotic (op/op) mice fail to exhibit bone remodeling because of a defective osteoclast
formation due to a lack of macrophage colony-stimulating factor. In this study, we
investigated the femora of op/op mice to clarify whether the osteoblastic population and
bone mineralization are involved in osteoclasts or their bone resorption. The op/op mice
extended the meshwork of trabecular bones from the chondro-osseous junction to the
diaphyseal region. In the femoral metaphyses of op/op mice, intense alkaline phosphatase …
formation due to a lack of macrophage colony-stimulating factor. In this study, we
investigated the femora of op/op mice to clarify whether the osteoblastic population and
bone mineralization are involved in osteoclasts or their bone resorption. The op/op mice
extended the meshwork of trabecular bones from the chondro-osseous junction to the
diaphyseal region. In the femoral metaphyses of op/op mice, intense alkaline phosphatase …